Publications
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2
1. Yuan S, Yin X, Meng X, Chan JF, Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan CC, Poon VK, Lee AC, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W, Lau CY, Sit KY, Au WK, Wang R, Zhang YY, Tang YD, Clausen TM, Pihl J, Oh J, Sze KH, Zhang AJ, Chu H, Kok KH, Wang D, Cai XH, Esko JD, Hung IF, Li RA, Chen H, Sun H, Jin DY, Sun R*, Chanda SK*, Yuen KY*. Clofazimine broadly inhibits coronaviruses including SARS-CoV-2. Nature. 2021 May;593(7859):418-423. doi: 10.1038/s41586-021-03431-4. Epub 2021 Mar 16. PMID: 33727703.
mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1
Du Y, Hultquist JF, Zhou Q, Olson A, Tseng Y, Zhang TH, Hong M, Tang K, Chen L, Meng X, McGregor MJ, Dai L, Gong D, Martin-Sancho L, Chanda S, Li X, Bensenger S, Krogan NJ, Sun R. mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1. Nat Commun. 2020 May 15;11(1):2449. doi: 10.1038/s41467-020-16140-9. PMID: 32415096; PMCID: PMC7229031.
DNA-Packing Portal and Capsid-Associated Tegument Complexes in the Tumor Herpesvirus KSHV
Gong D, Dai X, Jih J, Liu YT, Bi GQ, Sun R*, Zhou ZH*. DNA-Packing Portal and Capsid-Associated Tegument Complexes in the Tumor Herpesvirus KSHV. Cell. 2019 Sep 5;178(6):1329-1343.e12. doi: 10.1016/j.cell.2019.07.035. Epub 2019 Aug 22. PMID: 31447177; PMCID: PMC6753055.
Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells
Thaker SK, Chapa T, Garcia G Jr, Gong D, Schmid EW, Arumugaswami V, Sun R*, Christofk HR*. Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells. Cell Metab. 2019 May 7;29(5):1206-1216.e4. doi: 10.1016/j.cmet.2019.01.024. Epub 2019 Feb 28. PMID: 30827860; PMCID: PMC6818653.
Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design
Du Y, Xin L, Shi Y, Zhang TH, Wu NC, Dai L, Gong D, Brar G, Shu S, Luo J, Reiley W, Tseng YW, Bai H, Wu TT, Wang J, Shu Y, Sun R.Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design.Science. 2018 Jan 19;359(6373):290-296. doi: 10.1126/science.aan8806. PMID: 29348231.
Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication
Dai X, Gong D, Lim H, Jih J, Wu TT, Sun R*, Zhou ZH*. Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication. Nature. 2018 Jan 25;553(7689):521-525. doi: 10.1038/nature25438. Epub 2018 Jan 17. PMID: 29342139; PMCID: PMC6039102.
Systematic identification of anti-interferon function on hepatitis C virus genome reveals p7 as an immune evasion protein
Qi H, Chu V, Wu NC, Chen Z, Truong S, Brar G, Su SY, Du Y, Arumugaswami V, Olson CA, Chen SH, Lin CY, Wu TT, Sun R*.Systematic identification of anti-interferon function on hepatitis C virus genome reveals p7 as an immune evasion protein.Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2018-2023. doi: 10.1073/pnas.1614623114. Epub 2017 Feb 3. PMID: 28159892; PMCID: PMC5338388.
In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus
Dai X, Li Z, Lai M, Shu S, Du Y, Zhou ZH*, Sun R*.In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus.Nature. 2017 Jan 5;541(7635):112-116. doi: 10.1038/nature20589. Epub 2016 Dec 19. PMID: 27992877; PMCID: PMC5701785.
Adaptation in protein fitness landscapes is facilitated by indirect paths
Wu NC, Dai L, Olson CA, Lloyd-Smith JO, Sun R. Adaptation in protein fitness landscapes is facilitated by indirect paths. Elife.2016 Jul 8;5:e16965. doi: 10.7554/eLife.16965. PMID: 27391790; PMCID: PMC4985287.
Single-round, multiplexed antibody mimetic design through mRNA display
Olson CA, Nie J, Diep J, Al-Shyoukh I, Takahashi TT, Al-Mawsawi LQ, Bolin JM, Elwell AL, Swanson S, Stewart R, Thomson JA, Soh HT, Roberts RW, Sun R. Single-round, multiplexed antibody mimetic design through mRNA display.Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12449-53. doi: 10.1002/anie.201207005. Epub 2012 Nov 4. PMID: 23125174; PMCID: PMC3832244.